منابع مشابه
The prevalence of undesired blood group antibodies in thalassemia patients
Abstract Background and Objectives Blood transfusion related alloimmunization is common among patients receiving regular blood transfusion, especially thalassemia patients. In this study we aimed to find the prevalence of alloimmunization among patients of thalassemia. Materials and Methods In this desciptional study, we screened 305 thalassemia patients (53.8% female and 46.2% male, age ...
متن کاملNew and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes.
BACKGROUND In the ABO blood group system mutations in the A gene may lead to weak A subgroups owing to a dysfunctional 3-alpha-N-acetylgalactosaminyltransferase. STUDY DESIGN AND METHODS Blood and DNA were investigated to correlate weak A phenotypes with genotype, and an overrepresentation of the infrequent O2 allele was observed. Consequently, 57 available O2 alleles were examined in detail....
متن کاملEvolution of the O alleles of the human ABO blood group gene.
BACKGROUND To date, at least 40 different alleles O have been characterized on the basis of exon 6 and exon 7 sequences but not always for intron 6. STUDY DESIGN AND METHODS Among 415 individuals, from four continents (Africa, Europe, South America, and Asia), studied for exon 6 and exon 7 sequences, we selected 46 individuals (of respective phenotypes O [39], AB [3], B [3], or A [1]) for seq...
متن کاملThe incidence of spontaneous abortion in mothers with blood group O compared with other blood types
Although ABO incompatibility between mother and fetus has long been suspected as cause of spontaneous abortion in man, its precise contribution has not been completely resolved. In spite of reports in which the incompatible mating was recognized to be a cause of habitual abortion, and which eventually results in infertility or a reduction in the number of living children compared with the numbe...
متن کاملMolecular genetic analysis of the ABO blood group system: 1. Weak subgroups: A3 and B3 alleles.
We have determined the nucleotide sequences of the coding region in the last two coding exons of ABO genes (which occupy 91% of the soluble form of A1 transferase) from 7 individuals with weak subgroup phenotypes. Four of the individuals had an A3 phenotype and 3 individuals had a B3 phenotype. We determined the nucleotide sequences based on PCR followed by subcloning and DNA sequencing of the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Transfusion
سال: 2019
ISSN: 0041-1132,1537-2995
DOI: 10.1111/trf.15514